Dr. Leslie David Sims, a consultant for Asia Pacific Veterinary Information Service, Australia, said research collected since the first outbreaks of highly pathogenic avian influenza (HPAI) in the 1990s demonstrates successful application of vaccination can be effective in controlling and stopping the spread of HPAI.
During the Watt Global Media webinar, Vaccination as Part of an Avian Flu Eradication Plan, Sims presented information on how the use of vaccination has controlled and eliminated avian influenza viruses in nations other than the U.S. in the past.
Sims, who’s worked as a consultant for the Food and Agriculture Organization of the United Nations and the World Bank, has advised veterinary authorities in China, Thailand, Cambodia, North Korea, Mongolia, Indonesia and Vietnam. His presentation centered on lessons learned in almost two decades of fighting and studying the so-called “goose Quandong” strain of the HPAI virus in Southeast Asia.
Stamping out, culling of infected and susceptible flocks, has long been viewed as the only way to control the spread of HPAI. Sims said that’s not exactly true.
While this approach to stamping out does work if new cases are detected early and the response is rapid, it comes at a high cost. During the 2014-2015 HPAI outbreak in the U.S., he estimated 49 million birds were killed or culled. Sims said stamping out also depends on the density of poultry being low and is ineffective if the cull happens after the virus has already been transmitted to other flocks.
Vaccination, when used in combination with other biosecurity measures, can be just as effective in stopping the spread and eliminating the spread of HPAI. Sims noted that vaccination – without preemptive culling – was successful in stopping the spread of HPAI in Hong Kong in 2002. In 2003, vaccination, in combination with quarantine and depopulation of affected houses, was successful in stopping an outbreak that had already begun. More recently, Sims said, vaccination has been used successfully in Italy and with low pathogenic avian influenza in the U.S.
Vaccination works best when the vaccine’s antigen closely matches the genetic makeup of the pathogen, Sims said. An early response to an outbreak, as well as bio-secure administration by competent veterinary services is necessary to the success of an immunization program, too. Cooperation among government agencies and poultry industries and close monitoring of flocks are also needed.
“It’s great to have the vaccine and, hopefully, you won’t have to use it,” Sims said.
While empirical evidence demonstrates vaccination is successful, there is significant skepticism about the practice in the poultry industry. Sims said that likely comes from the inability to eliminate HPAI with vaccination in regions where it is endemic, concerns about the process of vaccination rather than the vaccine itself, concerns vaccines will be ineffective against new strains of HPAI, mistaken beliefs that only mass depopulation works and international trade concerns raised by wide-spread vaccination to prevent the spread of HPAI. Some countries, he said, will stop imports because of vaccination. However, China – where vaccination has been used for more than a decade – is still exporting poultry to Japan.
“They do this from areas where vaccine is not being used, but it shows it is possible for some countries to accept products from countries where vaccine is being used even though the product which is being exported is not subject to vaccination in those cases,” Sims said.
According to the latest report from the agriculture ministry in France, dated December 18, avian influenza has been confirmed at 42 locations – 12 more than the previous report 2 days earlier. A sixth department (region) has been affected in the southwest of the country – Hautes Pyrénées – which borders Spain. Other regions affected are Landes (18 outbreaks), Dordogne (12), Gers (6), Pyrénées Atlantiques (4) and Haute Vienne (1).
The highly pathogenic avian influenza (HPAI) virus of an H5 subtype has been confirmed at most of the affected premises – generally prior to the birds being transported to the slaughterhouse - and the majority of birds affected so far have been ducks.
New cases in Landes were revealed at 4 locations when birds were tested prior to slaughter in the communities of Montaut, Saint Sever, Aubagnan and Eyres Moncube. In each case, samples taken tested positive for a highly pathogenic H5 form of the AI virus. In another outbreak in the region, both the H5N2 and H5N9 virus variants have been found in a domestic duck flock in Saint Cricq en Chalosse.
H5 HPAI has been detected in one new flock in Dordogne – at Lardin Saint Lazare, near a previous outbreak – prior to movement and slaughter.
The new cases in Gers, all also confirmed as H5 HPAI prior to transportation to the abattoir - are in ducks in Cazaubon, Eauze and Caupenne d'Armagnac.
Two duck flocks in Pyrénées Atlantiques tested positive in Maucor and Saint Jammes.
In Hautes Pyrénées, the HPAI virus was found at Labatut-Rivière during testing following an earlier outbreak nearby in Arroses.
Work is ongoing in each case to identify the variant(s) of the AI virus involved.
The latest update from the World Health Organization (WHO) puts the total number of confirmed cases of influenza A (H5N1) since 2003 at 844, including 449 deaths.
Since the last update in November 2015, no new laboratory-confirmed human cases have been reported to WHO. So far in 2015, there have 143 cases, including 42 deaths, making it the worst year for this disease for the last 5 years. Worst-affected in 2015 was Egypt (136 cases, 39 deaths), with China (5 cases, 1 death) and Indonesia (2 cases, both died) also reporting outbreaks.
Commenting on the possible threat posed to human health of the latest outbreaks in French poultry, WHO states that, based on preliminary data, at least one of the viruses has different origins from the influenza A (H5) viruses that have caused human cases in the past. WHO says it is in contact with the animal health authorities to understand these viruses better and to assess the public health risk more accurately.
For avian influenza A (H7N9), WHO has received reports of two new confirmed human cases of infection in China, both of which reportedly had exposure to domestic poultry. This brings the total of confirmed cases of this virus in humans to 683, including at least 275 deaths. In 2015, the virus has been detected in the animal population in multiple provinces in China, indicating that the virus persists in the poultry population. If the pattern of human cases follows the trends seen in previous years, the number of human cases may rise over the coming months.
Since its previous update a month ago, WHO has been informed of 4 confirmed human cases of the avian influenza A (H9N2) virus infection in people in China. All of the cases were reported to have mild disease and none was hospitalized.
The highly pathogenic avian influenza (HPAI) virus of an H5 subtype has been confirmed at most of the affected premises – generally prior to the birds being transported to the slaughterhouse - and the majority of birds affected so far have been ducks.
New cases in Landes were revealed at 4 locations when birds were tested prior to slaughter in the communities of Montaut, Saint Sever, Aubagnan and Eyres Moncube. In each case, samples taken tested positive for a highly pathogenic H5 form of the AI virus. In another outbreak in the region, both the H5N2 and H5N9 virus variants have been found in a domestic duck flock in Saint Cricq en Chalosse.
H5 HPAI has been detected in one new flock in Dordogne – at Lardin Saint Lazare, near a previous outbreak – prior to movement and slaughter.
The new cases in Gers, all also confirmed as H5 HPAI prior to transportation to the abattoir - are in ducks in Cazaubon, Eauze and Caupenne d'Armagnac.
Two duck flocks in Pyrénées Atlantiques tested positive in Maucor and Saint Jammes.
In Hautes Pyrénées, the HPAI virus was found at Labatut-Rivière during testing following an earlier outbreak nearby in Arroses.
Work is ongoing in each case to identify the variant(s) of the AI virus involved.
Update on global avian flu situation in humans
Official agencies in France are stressing that the HPAI in poultry flocks there poses no danger to human health through the consumption of poultry meat and other products.The latest update from the World Health Organization (WHO) puts the total number of confirmed cases of influenza A (H5N1) since 2003 at 844, including 449 deaths.
Since the last update in November 2015, no new laboratory-confirmed human cases have been reported to WHO. So far in 2015, there have 143 cases, including 42 deaths, making it the worst year for this disease for the last 5 years. Worst-affected in 2015 was Egypt (136 cases, 39 deaths), with China (5 cases, 1 death) and Indonesia (2 cases, both died) also reporting outbreaks.
Commenting on the possible threat posed to human health of the latest outbreaks in French poultry, WHO states that, based on preliminary data, at least one of the viruses has different origins from the influenza A (H5) viruses that have caused human cases in the past. WHO says it is in contact with the animal health authorities to understand these viruses better and to assess the public health risk more accurately.
For avian influenza A (H7N9), WHO has received reports of two new confirmed human cases of infection in China, both of which reportedly had exposure to domestic poultry. This brings the total of confirmed cases of this virus in humans to 683, including at least 275 deaths. In 2015, the virus has been detected in the animal population in multiple provinces in China, indicating that the virus persists in the poultry population. If the pattern of human cases follows the trends seen in previous years, the number of human cases may rise over the coming months.
Since its previous update a month ago, WHO has been informed of 4 confirmed human cases of the avian influenza A (H9N2) virus infection in people in China. All of the cases were reported to have mild disease and none was hospitalized.


