Biomin will introduce FUMzyme, a new approach in counteracting fumonisins in animal production, during VIV Asia 2013. FUMzyme is a purified enzyme that biotransforms fumonisins into non-toxic metabolites in the gastrointestinal tract of animals.
The detoxifying activity of this enzyme was confirmed in numerous in vitro and in vivo experiments, according to Biomin. "Fumonisins elicit a toxic effect on the sphingolipid metabolism," said Ursula Hofstetter, director of the Competence Center Mycotoxins at Biomin. "The ratio of the sphingoid bases sphinganine and sphingosine in serum serves as an indicator (biomarker) of the effects of fumonisin on animals. For the first time, using the sphinganine/sphingosine ratio (Sa/So) as a biomarker, the detoxification of fumonisins by FUMzyme can be clearly demonstrated."
Climate change and the international transportation of raw materials are only two of several factors that increase fumonisin contamination all over the world. Recent findings have revealed natural fumonisin contamination levels of 77 ppm in finished animal feed. Pig and poultry farmers are not only suffering from unidentified losses in performance and immunosuppressive effects, but also species-specific clinical problems. So far, the only existing possibility of alleviating fumonisin intoxication was to bind fumonisins by adsorptive substances. Unfortunately, due to the molecular structure of these mycotoxins and the pH dependence of the reaction, it can only be insufficiently adsorbed in the gastrointestinal tract.
FUMzyme provides a way to counteract mycotoxins.
VIV Asia 2013 will take place in Bangkok, Thailand, March 13-15.
The detoxifying activity of this enzyme was confirmed in numerous in vitro and in vivo experiments, according to Biomin. "Fumonisins elicit a toxic effect on the sphingolipid metabolism," said Ursula Hofstetter, director of the Competence Center Mycotoxins at Biomin. "The ratio of the sphingoid bases sphinganine and sphingosine in serum serves as an indicator (biomarker) of the effects of fumonisin on animals. For the first time, using the sphinganine/sphingosine ratio (Sa/So) as a biomarker, the detoxification of fumonisins by FUMzyme can be clearly demonstrated."
Climate change and the international transportation of raw materials are only two of several factors that increase fumonisin contamination all over the world. Recent findings have revealed natural fumonisin contamination levels of 77 ppm in finished animal feed. Pig and poultry farmers are not only suffering from unidentified losses in performance and immunosuppressive effects, but also species-specific clinical problems. So far, the only existing possibility of alleviating fumonisin intoxication was to bind fumonisins by adsorptive substances. Unfortunately, due to the molecular structure of these mycotoxins and the pH dependence of the reaction, it can only be insufficiently adsorbed in the gastrointestinal tract.
FUMzyme provides a way to counteract mycotoxins.
VIV Asia 2013 will take place in Bangkok, Thailand, March 13-15.
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